What is glutathione?

Glutathione is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and a detoxifier and is a major defense system against illness and aging.  Our glutathione level indicates our state of health and can predict longevity. Although there are more than 99,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.

Increasing intracellular glutathione levels has been shown to:

• dramatically increase energy levels;
• strengthen the immune system;
• aids cell detoxification;
• chelate heavy metals like mercury (i.e., bind to heavy metals, so that they can be removed from the body);
• fights off the damage of free radicals on the cells;
• slow down the aging process;
• reduce inflammation or swelling;
• improve athletic performance and recovery;
• detoxify and improve liver function;
• increase stamina and endurance;
• improve memory and other mental functions;
• improve vision;
• improve heart and lung function;
• aids muscle and joint recovery;
• mood improvement;
• improves quality of sleep;
• improves the health of skin and decreases wrinkles;
• eases anxiety; and
• protects from degenerative diseases and reduces the chances of developing cancer (click here for a list of diseases and illnesses that are linked to low glutathione levels).

“Glutathione levels go down in every age group except one and that one are the people who reach a hundred years of age. Those people, interestingly, have glutathione levels that approximate those of a normal 30 to 40 year old.”
- Dr. Keller

Glutathione levels decrease as a result of:

• aging (glutathione levels decrease by 10-15% every decade);
• stress;
• inflammation;
• sun exposure;
• athletic activities;
• sleep deprivation; and
• environmental toxins.

How do you increase glutathione levels?

Increasing  intracellular glutathione levels is typically a complicated process. Glutathione can be taken intravenously, transdermally or through a nebulizer. Note that supplementing directly with oral glutathione is generally not effective because studies have found that glutathione does not survive the digestive process. Furthermore, supplementing with oral glutathione can result in a yeast outbreak and gut imbalance. Injections are only minimally useful, since glutathione cannot enter into the cells themselves. It must be manufactured inside the cells (when the necessary components are available.) As Dr. Kartzinel explains, methyl B12 injections and supplementing with trimethylglycine (TMG) or dimethylglycine (DMG),  folic acid and N-acetyl-cysteine can increase glutathione levels.

An easy and effective way to increase glutathione levels

MaxGXL is a 100% natural supplement that increases intracellular glutathione levels by an average of 276%. MaxGXL does not contain glutathione (which breaks down during the digestive process), but contains ingredients that stimulate the production of glutathione,  including: vitamin C; N Acetyl cysteine, L-glutamine, N Acetyl D-glucosamine, quercetin, milk thistle extract, alpha lipoic acid, cordyceps and conjugated linoleir acid. Find out more about MaxGXL here.

More information:

• Watch a 14 min video of Dr. Keller discussing the science behind the importance of glutathione production here.
• Watch a 7 min video of Dr. Keller presenting information about the importance of glutathione in the aging process at the American Academy of Anti-Aging Conference here.
• Watch Dr. Oz’s video about the importance of glutathione here.
• Watch Dr. Oz’s video about the importance of glutathione here.
• Glutathione: The Mother of all Anti-oxidants by Dr. Mark Hyman.
• Glutathione: The Great Protector by Catherine Guthrie
• A 16 page article of the importance of glutathione here.

What is MaxGXL?

MaxGXL is a 100% natural supplement that has been scientifically proven to increase glutathione levels by an average of 276%. MaxGXL does not contain glutathione (which breaks down during the digestive process, but contains ingredients that stimulate the production of glutathione),  including: vitamin C; N Acetyl cysteine, L-glutamine, N Acetyl D-glucosamine, quercetin, milk thistle extract, alpha lipoic acid, cordyceps and conjugated linoleir acid. More information about the benefits of each of these ingredients is described below.

People generally experience these benefits of taking MaxGXL:

• More natural energy – – less likely to tire throughout the day
• Less joint and muscle aches and pains
• Decreased pain in general
• Mood improvement
• Sharper state of mind, mental clarity, and focus
• Younger looking skin – less dry skin, reduced appearance of wrinkles, etc.
• Better sleep – more dreaming and remembering your dreams
• More stamina and endurance – less recovery time after working out
• Better memory
• Reduced inflammation or swelling
• Improved vision
• Improved breathing

MaxGXL is different from an oral glutathione supplement (which is broken down during the digestive process) and is the result of years of experimentation, all culminating in the creation of a blend of the appropriate ingredients in proportionally correct amounts, enabling it to:

1) Utilize the digestive system as a tool, not a hurdle

2) Be preferentially absorbed (because not everything you put into your mouth gets absorbed into your body)

3) Have the ability to pass through two critical membranes – one at the entrance to the cell, and a second at the entrance to that furnace inside each cell called the mitochondria.

4) Have the ability to recycle the spent glutathione through the liver after it has been utilized to eliminate the oxidants that are the byproduct of ATP production within the mitochondria.

Clinical Studies

Dr. Keller’s double-blind placebo controlled, cross-over clinical study on MaxGXL on healthy individuals demonstrated that in only 60 days of use of MaxGXL, every person had an average of:

• 276% increase in intracellular glutathione;
• 46% increase in DHEA and 41% IGF-1 (markers for adrenal function and human growth hormone); and
• 61% decrease in TNF-alpha (marker for cellular inflammation). Read the results of the clinical study here.

Dr. Keller actually developed MaxGXL in response to the needs of his patients, and clinical studies were conducted on some of his patients.

MaxGXL has been demonstrated to raise glutathione levels even in individuals who are immune compromised. The graph below shows the increase in glutathione levels experienced by 4 groups of patients. Group 1 (normal health patients) were tested after 6 months of use, while Groups 2, 3 and 4 (HIV, Hepatitis C, and Chronic Viral Illness respectively) were tested after only 3 months of the MaxGXL regimen. All four groups did have a substantial increase in their blood lymphocyte glutathione levels (211%, 416%, 347% and 270% after 6 months, 3 months, 3 months, and 3 months respectively in normal volunteers, HIV (Human Immunodeficiency Virus) patients, HCV (Hepatitis C virus) patients, and CFIDS/chronic viral illness patients). Source here.

Read an endorsement letter about MaxGXL by four internal medicine physicians here. Listen to Dr. Patricia Wendel’s endorsement of MaxGXL here.

Virtually everyone who takes Max products consistently for three months feels a difference (i.e., higher energy levels and other health benefits). 75% of people feel a difference within a week, and 90% within two weeks feel a difference. I felt a difference in my mental clarity within hours of first taking MaxGXL. The clinical study demonstrated that 100% of the people taking MaxGXL increased their intracellular glutathione levels by an average of 276% after 60 days.

MaxGXL is 100% natural. No sugar, starch, yeast, soy, dairy, gluten or preservatives.

MaxGXL contains:

Vitamin C ( as calcium ascorbate) 250mg
Calcium Ascorbate is an optimal nutritional supplement that combines Ascorbic Acid (Vitamin C) with Calcium Carbonate. By combining these two dietary ingredients, it is a buffered source of Vitamin C that will not contribute to gastric irritation in sensitive persons.

N Acetyl Cysteine 375 mg
N-Acetyl cysteine is derived from the sulfur-containing amino acid, cysteine. It is produced naturally in the body and is also obtained from the diet. Along with glutamic acid and glycine NAC is a precursor to glutathione, which is the body’s most important cellular antioxidant. Proponents of NAC find that NAC is an immune enhancer; prevents and treats cancer; detoxifies heavy metals; treats smoker’s cough and bronchitis; prevents heart disease; slows progression of HIV; relieves hangover symptoms; reduces exercise fatigue. It is used as a supplement for bronchitis, HIV infection, cystic fibrosis, cancer chemotherapy support, acetaminophen poisoning, heavy metal poisoning, and septic shock.

I-Glutamine 750 mg
This is the most abundant of the amino acids in the human body. Its main storage site is in the musculature, where about 60% of all the unbound amino acids are glutamine (glutamine makes up a smaller percentage of muscle protein, the main bound form). Glutamine has been called a “conditionally essential” nutrient , because it is non-essential in normal situations (manufactured by the body in adequate quantities; not required in the diet), but in illness or injury becomes insufficient (there is then a need for supplementation from the diet or other sources).

N Acetyl D-Glucosamine 125 mg
Used to strengthen immune function & is one of the building blocks of joint tissue and other connective tissues .In certain studies has been known to restrain and treat cancer. As to all kinds of inflammations, it is able to aid in therapy effectively. And also bone arthritis and joint pains have been reduced with using it alone or together with MSM.

Quercetin 37.5mg
This is an anti-oxidant that belongs to a group of plant pigments called flavonoids that are largely responsible for the colors of many fruits, flowers, and vegetables. Flavonoids, such as quercetin, provide many health-promoting benefits. They act as antihistamines (which are useful in reducing allergy symptoms) and help reduce inflammation associated with various forms of arthritis. Quercetin also works as an antioxidant by scavenging damaging particles in the body known as free radicals. These particles occur naturally in the body but can damage cell membranes, interact with genetic material, and possibly contribute to the aging process as well as the development of a number of conditions including heart disease and cancer. Antioxidants such as quercetin can neutralize free radicals and may reduce or even help prevent some of the damage they cause.

Milk Thistle extract 25mg (Silybum marianum)
Milk Thistle has been used since Greco-Roman times as an herbal remedy for a variety of ailments, particularly liver problems. In the late 19th and early 20th centuries physicians in the United States used milk thistle seeds to relieve congestion of the liver, spleen, and kidneys. Today, several scientific studies suggest that active substances in milk thistle (particularly silymarin) protect the liver from damage caused by viruses, toxins, alcohol, and certain drugs such as acetaminophen (a common over the counter medication used for headaches and pain; acetaminophen, can cause liver damage if taken in large quantities or by people who drink alcohol regularly.)

Alpha lipoic Acid 75mg
Quite Possibly the “Universal” Antioxidant. The body needs ALA to produce energy. It plays a crucial role in the mitochondria, the energy-producing structures in cells. The body actually makes enough ALA for these basic metabolic functions. This compound acts as an antioxidant, however, only when there is an excess of it and it is in the “free” state in the cells. But there is little free ALA circulating in your body, unless you consume supplements or get it injected. Foods contain only tiny amounts of it. What makes ALA special as an antioxidant is its versatility—it helps deactivate an unusually wide array of cell-damaging free radicals in many bodily systems. In particular, ALA helps protect the mitochondria and the genetic material, DNA. As we age, mitochondrial function is impaired, and it’s theorized that this may be an important contributor to some of the adverse effects of aging. ALA also works closely with vitamin C and E and some other antioxidants, “recycling” them and thus making them much more effective.

Cordyceps 300mg
Cordyceps sinensis, known in China as Dong Chong Xia Cao (“Summer Grass, Winter Worm”) and in the West as Cordyceps or The Caterpillar Fungus, has long been used in Traditional Chinese Medicine for the promotion of cardiovascular, sexual and immune system health and as a general energizing tonic, as it oxygenates the blood. Traditional Chinese Medicine have used it to treat fatigue and other ailments for 1,500 years.

Conjugated linoleic acid 100mg
A naturally occurring free fatty acid . Used in small amounts it is a newly discovered good fat that may be a potent cancer fighter. In studies, very small amounts of CLA have blocked all three stages of cancer: 1) initiation, 2) promotion, and 3) metastasis. Most anti-cancer agents block only one of these stages. What’s more, CLA has slowed the growth of an unusually wide variety of tumors, including cancers of the skin, breast, prostate, and colon. Also know to aid in weight loss and the conversion of fat to lean muscle mass and is used extensively by body builders and weight loss professionals. So it is a naturally occurring nutrient with the ability to help you pack on lean muscle, reduce body fat and at the same time possesses health promoting properties.

Other ingredients: Gelatin capsule (MaxGXL Sport is a vegetable capsule).

Allergy warning: MaxGXL is derived from mushroom and shellfish. If you (or your child) is allergic to mushrooms and shellfish, you can use the MaxOne product, which is not derived from mushrooms and shellfish.

The information described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. MaxGXL does not cure or treat any disease or illness. It simply gives your cells the nutrients they need to produce more glutathione, which in turn helps every cell function better.

Diseases and illnesses linked to low glutathione levels

Glutathione has been widely studied with over 99,000 published peer-reviewed scientific papers on this topic. In one review, almost 80% of people with chronic ailments were found to be deficient in glutathione. In fact, low levels of glutathione are involved in all disease states. The following symptoms, diseases and illnesses have been linked to low glutathione levels (see full list here). (To find the scientific papers that have been published on each of these topics in relation to glutathione, visit www.pubmed.gov and type in “glutathione” and the symptom/disease/illness/syndrome of interest).

This list is substantial simply because glutathione is present in every cell in the body. Given that glutathione is the body’s master antioxidant and detoxifier, increasing intracellular glutathione levels allow all of your cells in your body to detoxify and to work more efficiently and effectively.

General reading:

• Read an interview with Dr. Don Colbert here, which describes the importance of increasing glutathione levels for overall health.
• Watch a 3 min Dr. Oz video discussing the importance of increasing glutathione levels for all health concerns here.
• Read  Ballatori et al.’s  (2009) paper, Glutathione dysregulation and the etiology and progression of human diseases.
• Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issuesacetaminophen (i.e., Tylenol) toxicity
  • read these scientific papers about acetaminophen toxicity and glutathione here.
  • Note: The number one cause of acute liver failure in the US is from taking acetaminophen (read article here)
  • Glutathione can be used to reduce acetaminophen toxicity.
• acne
  • 13 scientific papers here
  • an article about how increasing glutathione levels can help acne here
• addictions (including tobacco)
  • 8 scientific papers here
• AIDS and HIV
  • 322 scientific papers here
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here.
  • Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS. Proceedings of the National Academy of Science, USA 94: 1967-72, 1997.
  • read this scientific paper entitled “Glutathione and immune function” here. “Two randomized placebo-controlled trials have shown that treatment of HIV-infected patients with N-acetyl-cysteine caused in both cases a significant increase in all immunological functions under test, including an almost complete restoration of natural killer cell activity”
  • Glutathione deficiency is associated with impaired survival in HIV disease “Clinical studies presented here directly demonstrate that low GSH levels predict poor survival in otherwise indistinguishable HIV-infected subjects.”
  • Intracellular Glutathione Levels in T Cell Subsets Decrease in HIV-Infected Individuals “These findings suggest that low intracellular GSH levels may be an important factor in HIV infection and in the resulting immunodeficiency.”
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • Read the American Healthcare Foundation’s article about glutathione and HIV here. “Researchers have discovered that, among other biochemical changes, HIV/AIDS patients experience unusually low GSH concentrations. Some have reported that GSH levels in the blood fall to about 30% of normal. They suggest that this deficiency contributes to the typical feature of HIV infection — progressive weakening of the immune system. Scientific studies have shown that supplementation aimed at maintaining GSH levels can diminish and sometimes reverse the wasting effects of AIDS.”
  • Dr. Keller’s article about glutathione and HIV here
  • read these scientific papers about HIV and glutathione here
  • Clinical studies on MaxGXL included individuals with HIV patients; HIV patients experienced a 347% increase in glutathione levels over a 3 month period (graph provided here)
• aging
  • It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging including cataracts, Alzheimer’s, Parkinson’s atherosclerosis and others. Journal of Clinical Epidemiology 47:1021-26, 1994.
  • “Glutathione levels go down in every age group except one and that one are the people who reach a hundred years of age. Those people, interestingly, have glutathione levels that approximate those of a normal 30 to 40 year old.” – Dr. Keller
  • Glutathione, oxidative stress and aging “The involvement of glutathione in aging has been known since the early seventies. Recent experiments from our laboratory have underscored the importance of cellular compartmentation of glutathione. Mitochondrial glutathione plays a key role in the protection against free radical damage associated with aging.
  • Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA “This relationship, which has been observed for the first time in these studies, underscores the role of glutathione in the protection against free radical damage that occurs upon aging.”
  • Subcellular compartmentalization of glutathione: Correlations with parameters of oxidative stress related to genotoxicity “The findings highlight the critical roles of the mitochondrial and nuclear GSH pools in protecting cellular components, particularly DNA, from oxidative modification.” 
  • Oxidative stress and aging: is aging a cysteine deficiency syndrome? “These findings suggest: (i) that loss of youth, health and quality of life may be partly explained by a deficit in cysteine and (ii) that the dietary consumption of cysteine is generally suboptimal and everybody is likely to have a cysteine deficiency sooner or later.”
  • James F. Balch MD and Phyllis A. Balch, C.N.C.: Prescription for Nutritional Healing – Second Edition “As we age, glutathione levels decline, although it is not known whether this is because we use it more rapidly or produce less of it to begin with. Unfortunately, if not corrected, the lack of glutathione in turn accelerates the aging process.”
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • read a general article about the free radical theory of aging and the antioxidant revolution here
  • 9 minute video about the link between aging, falling glutathione levels and the onset of disease here
  • Watch a 7 min video of Dr. Keller presenting information about the importance of glutathione in the aging process at the American Academy of Anti-Aging Conference here.
  • listen to a 6 min video of Dr. Rex Anderson, a neurologist, discussing glutathione and the diseases of aging here
• alcoholism
  • 288 scientific papers here
  • Mitochondrial glutathione depletion in alcoholic liver disease. “The profound and selective mitochondrial GSH depletion precedes the onset of alcoholic liver disease, mitochondrial lipid peroxidation, and progression of liver damage.”
  • The Effects of Chronic Alcohol Abuse on Pulmonary[Lung] Glutathione Homeostasis “We determined that otherwise  alcoholics had significantly decreased ELF [lung lining fluid] concentrationsof GSH compared with nonalcoholic control subjects (79 µmol vs 576 µmol, p < 0.001)”
  • Lauterburg BH; Velez, ME, Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut. 1988 Sep;29(9):1153-7.
  • Moss, M; Guidot, D; Wong-Lambertina, M; Hoor, T; Perez, R; Brown, LA, The Effects of Chronic Alcohol Abuse on Pulmonary Glutathione Homeostasis. Am J Respir Crit Care Med. 2000;161:414-419.
  • The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raisied glutathione levels help restore liver function. American Journal of gastroenterology 91: 2569-2573, 1996
• allergies
  • read this article written by the American HealthCare Foundation about the about the role of allergies and glutathione here. “Fighting oxidative damage high GSH levels may help prevent the following complications of allergy: discomfort during the allergic reaction; disruption of normal lifestyle; anaphylaxis and side effects of medications”
• ALS (amyotrophic lateral sclerosis or Lou Gehrig’s disease)
  • Tohgi et al. Increase in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis.Neurosci Lett. 1999 Feb 5; 260(3):204-6.
  • Glutathione, oxidative stress and neurodegeneration. There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Friedreich’s ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders.
  • After being given a glutathione IV dose to remove heavy metals stored in the brain, a Lou Gehrig’s patient showed 90 percent improvement within ten minutes. His joint pain was gone and his cognitive symptoms improved markedl. Read article here.
  • read these scientific papers about ALS and glutathione here.
• Alzheimer’s disease
  • 743 scientific papers here;
  • Glutathione, oxidative stress and neurodegeneration. There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Friedreich’s ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders.
  • Woltjer et al. Role of Glutathione in Intracellular Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and Associated Cytotoxicity. J Neurochem. 2005 May; 93 (4): 1047-56.
  • read these scientific papers about Alzheimer’s disease and glutathione here.
  • read this article by the American Healthcare Foundation about glutathione and Alzheimer’s here. ”It is unclear whether oxidative damage is the cause or just an effect of Alzheimer’s. Nevertheless, by maintaining adequate GSH levels their antioxidant function is maximized. By diminishing oxidative damage the progression of the disease can be retarded or diminished.”
• angina and spastic angina, unstable angina
  • 68 scientific papers here
• anxiety
  • 100 scientific papers here
  • Rosie’s video here
  • read Peter’s testimonial here
  • read Christeen’s and Ron’s testimonials here
• arthritis
  • 429 scientific papers here
  • Elevated levels of inflammatory markers were associated with a depletion of Glutathione in study subjects suffering from Lupus and Arthritis; scientific paper here.
  • The glutathione defense system in the pathogenesis of rheumatoid arthritis “Rheumatoid arthritis was associated with significant depletion (ca. 50%) in GSH levels compared with normal control subjects. .. The results support a hypothesis that defense mechanisms against reactive oxygen species are impaired in rheumatoid arthritis.”
  • Watch a video about orthopedic surgeon discussing osteoarthritis and glutathione here.
  • read Shirley’s testimonial here
  • read Kimberly’s, Kerry’s stepfather’s,  Mike’s, Gwendolyn’s and Michelle’s testimonials here
  • read Tolbert’s testimonial here
• asthma
  • 548 scientific papers here
  • Kloek J, Mortaz E, Van Ark I, Lilly CM, Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in guinea pigs. Journal of Physiology and Pharmacology 2010, 61, 1, 67-72
  • Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994
  • Read this article by the American Healthcare Foundation about glutathione and asthma here. “There is a direct correspondence between low glutathione levels and the severity of the asthma attack. European physicians have long used GSH precursors in the treatment of asthma, particularly as a mucolytic (phlegm thinner) to break down thick secretions.”
  • Watch Ty Sutherland’s testimonial on Youtube here. Two months after starting MaxGXL, he no longer needs any asthma medications and his energy levels are through the roof.
  • Read Lisa’s testimonial about how her son no longer suffers from asthma here.
• athletic performance
  • Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge. Journal of Applied Physiology 87: 1381-1385, 1999.
• atopic dermatitis
  • 29 scientific papers here
  • Blood glutathione-peroxidase levels in skin diseases “Depressed [glutathione] levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis”
• attention deficit disorder (ADD) and ADHD
  • 9 scientific papers here
  • This scientific study discusses how glutathione production is decreased in children with ADHD
  • Read Robin’s testimonial about her grandson with ADHD and depression, whose behaviour improved dramatically after starting MaxGXL here. Watch the video here.
• autism
  • 56 scientific papers here;
  • read these scientific papers about autism and glutathione here
  • Click here for article about autism and glutathione published in the American Journal of Clinical Chiropractic.
  • A large study by James et al confirmed her original finding of low glutathione in children with autism due to abnormalities in their methionine pathway. She also found that children with autism were more likely to have genetic polytypes associated with abnormalities in the methionine pathway. James et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):947-56.
  • Medical literature documents that an infection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant’s or toddler’s nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)
  • Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. This scientific study discusses how glutathione production is decreased in children with ADHD
  • Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15. “We conclude that that 45% of a subgroup of children with autism suffers from low NK cell activity, and that low intracellular levels of glutathione, IL-2 and IL-15 may be responsible.”
  • Mercury and autism: Accelerating Evidence? “The process of cysteine and glutathione synthesis, which are crucial for natural mercury detoxification, are reduced in autistic children, possibly due to genetic polymorphisms [13,30]. Therefore, autistics have 20% lower plasma levels of cysteine and 54% lower levels of glutathione, which, among others, adversely affect their ability to detoxify and excrete metals like mercury”
  • Biomarkers of environmental toxicity and susceptibility in autism. “Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, and sulfate were observed among study participants relative to controls. The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity.”
  • Scientific paper: “A clinical trial of glutathione supplementation in autism spectrum disorders” here (note that they did not test MaxGXL specifically, but this study shows that scientists feel that there is scientific merit to increasing glutathione levels in autistic children).
  • read an article by American Healthcare Foundation about glutathione and autism here.
  • “A study performed at the University of Arkansas for Medical Sciences College of Medicine suggested that excessive cellular oxidative stress may be a factor causing autism. In the study, researchers measured plasma glutathione and its metabolic precursors in 95 autistic children and 75 children without autism. It was found that levels of glutathione are significantly lower in autistic children than in the children without autism.”
  • an article discussing the importance of glutathione for detoxing heavy metals of autistic children here and here. Glutathione is the body’s chief detoxifier.  It works with MT proteins to remove heavy metals and other harmful substances like pesticides and PCBs. Dr. S. Jill James has shown that 90% of children on the  autism spectrum as well as their parents have impaired methylation.  The active form of glutathione is reduced 80% in kids with autism.
  • “Another recent study, to be published later this year, was conducted by Dr. Jill James of the Autism Speaks’ Autism Treatment Network. It relates to the mother’s inability to produce sufficient levels of a chemical called glutathione. The chemical is essential in fighting toxic metals in the body. Several studies have already established that high levels of toxic metals in children are strongly correlated with the severity of autism, Adams said. According to Adams, the glutathione study shows that low levels of glutathione, coupled with high production levels of another chemical, homocysteine, greatly increase the chances of a woman having a child with autism. Among “autism moms” in the study, 41 percent of them carried this chemical abnormality. “This is a big deal where it seems to account for many of the cases of Autism and seems to greatly increase the risk 46 times,” Dr. Adams said. In other words, moms who carry this abnormality of glutathione and homocysteine levels have a one in three chance of having a child with Autism, Adams said. Nationally, researchers estimate that mothers have a one in 150 chance of having a child with Autism.” article here
  • Notes from a recorded call by Dr. Corinne Allen about low glutathione levels and autism here;
  • Testimonials of parents with children with autism here;
  • a general article about the link between Parkinson’s disease and autism [i.e., low glutathione levels] here
• auto immune disorder
  • read about the benefits of raising glutathione levels and auto immune disorders here
  • read Joe’s testimonial about his wife’s recovery from Lupus after starting MaxGXL here
• back injury
  • read James’ testimonial here
  • read Tolbert’s testimonial about a herniate disc here
  • read Dena’s story here
• bird flu
  • 6 scientific papers here
• bipolar disorder
  • 12 scientific papers here
  • A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. When glutathione (GSH) levels are reduced there is an increased potential for cellular oxidative stress, characterised by an increase and accruement of reactive oxygen species (ROS). Oxidative stress has been implicated in the pathology of schizophrenia and bipolar disorder. Read this abstract here
• bowel
  • Sido B, Hack V, Hochlehnert A, Lipps H, Herfarth C, Dröge W, Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 42: 485-492, 1998. Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease.
• brain injuries / damage
  • 165 scientific papers here;
  • listen to a recorded call by Dr. Corinne Allen here about brain injuries and glutathione
  • read one person’s testimonial, a person who had a brain surgery for a mass on their brain here. She is now symptom-free, her personality has returned and she can remember things again.
  • Jain, A; Martensson J; Stole E; Auld P; Meister A, Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci. 1991 Mar;Vol 88:1913-1917.
• bronchitis
  • 58 scientific papers here
  • Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994
  • read Pam and Julie’s testimonials here (in the comments section) (they both no longer get bronchitis regularly like they used to).
• burn
  • read how Sona’s burn healed quickly here.
• cancer (all cancers, including brain, head and neck, thyroid, lung, esophagus, stomach, intestine, liver, pancreas, kidney, uterine, ovarian, prostrate, leukemia [acute and chronic]), lymphoma, multiple myeloma and others) (15,142 scientific papers here)
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here. This paper discusses how cancer patients have low glutathione levels and supplementation with cysteine can be a useful treatment (MaxGXL contains N-Acetyl Cysteine)
  • Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/antitumor defenses.  Cancer Letters 57: 91-94, 1991.
  • GSH and analogs in antiviral therapy. “GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx). An imbalance in GSH is observed in a wide range of pathologies, such as cancer, neurodegenerative diseases, cystic fibrosis (CF), several viral infections including HIV-1, as well as in aging.”
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • read these scientific papers about cancer and glutathione here
  • read this information about glutathione and cancer here (Dr. Daria Davidson recommends MaxGXL for approximately 50% of her cancer patients)
  • “The wealth of medical articles describing the role of GSH in cancer prevention and treatment – fall into three main groups: prevention (antioxidation, detoxification of carcinogens, heightened immune response); therapeudic (anti-tumour methodologies, malnutrition and wasting); and chemotherapy and radiotherapy (enhancing effectiveness, cells vulnerable to therapy, minimizing side-effects: less depression, less vomiting, less hair less, less shortness of breath, less neurotoxicity).” – quote from American Healthcare Foundation
  • Dr. Keller’s article about glutathione and cancer here
  • Dr. Keller discusses the benefits of using increasing glutathione levels for cancer patients on chemo therapy in this video here (around the 14:40 mark).
• breast cancer
  • read an article by the American Healthcare Foundation about glutathione and breast cancer here
  • read Claudia’s testimony about detoxing the silicon resulting from silicon implant burst here
• cervical cancer
  • read an article by the American Healthcare Foundation about glutathione and cervical cancer here.
  • watch Tammy’s video here.
• colon cancer
  • read an article by the American Healthcare Foundation about glutathione and colon cancer here
• leukemia
  • A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. We conclude that dominant apoptosis resistance depends, at least in part, on intracellular GSH levels, which may affect apoptosis signaling at different compartments, for example, the death receptor or mitochondria.
• lymphoma
  • read Lee’s testimony about his recovery from the chemo related to lymphoma here
• ovarian cancer
  • Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: Results of a doubleblind, randomised trial. Early clinical trials have suggested that glutathione offers protection from the toxic effects of cisplatin.
• pancreatic cancer
  • read Sherel’s dad’s story here
• prostrate cancer
  • read Tolbert’s testimonial here (now in remission)
• skin cancer
  • read Marie’s testimonial about how her precancerous skin cells were resolved here
• stomach cancer
  • read Carmen’s testimonial about how her daughter’s stomach  polyps no longer were cancerous here.
• candida
  • watch Maddie’s testimonial here
• cardiovascular health
  • listen to Dr. Jacob John, a cardiologist, discuss MaxGXL here.
• cataracts (779 scientific papers here)
• chemical sensitivities
  • read Shirley’s testimonial here
• cholesterol
  • “Raised glutathione levels fight the oxidation of circulating fats in the bloodstream, including cholesterol, retarding the process of plaque formation in the arteries – the underlying cause for most heart disease and stroke”. Nutrition Reviews 54:1-30, 1996.
  • read Ken’s testimonial here
  • read Claudia’s testimonial here
• chronic fatigue syndrome / myalgic encephalomyelitis (ME)
  • 27 scientific papers here
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here. This paper discusses how individuals with chronic fatigue syndrome are low in glutathione and supplementation with cysteine can be a useful treatment (MaxGXL contains N-Acetyl Cysteine)
  • Bounous et al. in 1999 proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and muscle pain associated with chronic fatigue syndrome.
  • read the American Healthcare Foundation’s article about the role of glutathione and chronic fatigue syndrome here. “While CFS is a toxicological problem – it is more typical of an immune disorder. It is best classified as a post-viral or post-infectious syndrome…Glutathione (GSH) detoxifies a large number of pollutants, carcinogens, heavy metals, herbicides, pesticides and radiation… By undergoing GSH enhancing therapy to combat oxidative damage, a major source of chronic fatigue syndrome complications, is addressed including: muscle and joint pain; continuous debilitating fatigue; and impaired short-term memory and concentration. Dr. Paul Cheney and numerous other CFS physicians have demonstrated that once your levels of GSH have returned to a level consistent to enabling proper immune system support, many patients respond with dramatic results.”
  • read Holly’s and Shirley’s testimonials here.
  • read Brian’s testimonial here
• colitis
  • 230 scientific papers here;
  • Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Gut 42: 485-492, 1998
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here. This paper discusses how individuals with colitis have low glutathione levels and supplementation with cysteine can be a useful treatment (MaxGXL contains N-Acetyl Cysteine)
• Crohn’s disease (67 scientific papers here; read one of the abstracts here)
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here. This paper also discusses Crohn’s disease and how it is a low glutathione syndrome and supplementation with cysteine can be a useful treatment (MaxGXL contains N-Acetyl Cysteine)
  • Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s di-ease. Gut 42: 485-492, 1998
  • Read Paul’s testimony, a man with Crohn’s disease here. By 7 weeks on MaxGXL, he was no longer experiencing pain or discomfort. Watch video here.
• cystic fibrosis
  • read these scientific papers about cystic fibrosis and glutathione here
  • Systemic deficiency of glutathione in cystic fibrosis. “The glutathione deficiency observed in ELF in CF patients is not limited to the site of the inflammation but is systemic.”
  • Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation. “Given the vital role of GSH as an antioxidant, a mucolytic, and a regulator of inflammation, immune response, and cell viability via its redox status in the human body, it is reasonable to hypothesize that this condition plays some role in the pathogenesis of CF. Therapeutic implications, including alternative methods of GSH augmentation, are discussed.”
  • Glutathione A Radical Treatment for Cystic Fibrosis Lung Disease? “Given that a number of inflammatory lung diseases share a diminished level of glutathione in the epithelial lining fluid and excessive lung inflammatory responses, a glutathione therapeutic may have broader implications than cystic fibrosis”
  • read the American Healthcare’s Foundation’s article about the role of glutathione and cystic fibrosis here. “Unlike most other tissues, the lungs can use GSH as-is — through direct contact — rather than having to first absorb its precursors and then manufacture it, as is the case elsewhere in the body. Elevated GSH levels may help cystic fibrosis patients by: providing immune system support against infection; supressing malabsorption of nutrients and, in turn, malnutrition; and slowing the progression of the disease”
• degenerative disc disease
  • Read Sally’s,  Julie’s and Shirley’s testimonies here
• dementia
  • 551 scientific papers here
• depression
  • 621 scientific papers here
  • Davies, B, Successful Treatment of Depression with IV Glutathione. Naturopathic Doctor News & Review. June 2008;Vol 4,Issue 6.
  • Barańczyk-Kuźma A, Kuźma M, Gutowicz M, Kaźmierczak B, Sawicki J, Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochemica Polonica. Vol 51;No 1, 2004:207-212.
  • read Shirley’s testimonial here
  • read Ron’s testimonial here
  • Watch Diana’s video here
  • read Dena’s story here
• diabetes
  • 2641 scientific papers here
  • read these scientific papers about diabetes and glutathione here
  • Mitochondrial glutathione (scientific review paper) – see p. 2694 for info re: diabetes
  • The blood and tissues of diabetics are marked by critically low glutathione levels.
  • De Mattia et al. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism. 1998 Aug;47(8):433-8.
  • Oxidative Stress and Glutathione Synthesis in Type 2 Diabetes “We conclude that subjects with type 2 diabetes have decreased oxidant capacity, evidenced by reduced synthesis of glutathione, and they are under increased oxidative stress”
  • Antioxidants in diabetes management “Administration of glutathione was found to be advantageous in type 2 diabetics and those with impaired glucose tolerance. Glutathione improved insulin secretion in patients with iGT. Glutathione also improves insulin sensitivity in patients with type 2 diabetes after acute and chronic administration.”
  • Diabetics are more prone to infections and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes. Clinical Science 91:575-582, 1996
  • listen to Dr. Keller speak about glutathione and diabetes here
  • Read Sally’s and Dave’s testimonials here
  • Read Larry’s and Christeen’s testimonials here
• detoxification
  • Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer. Annual Reviews of Biochemistry 52: 711-760, 1983
  • read a general article about the role of the liver and glutathione in the detoxification process here
• Down’s syndrome
  • read a testimony of an individual with Down’s syndrome that is now talking in full sentences as a result of MaxGXL here (in the comments section).
• eczema
  • 21 scientific papers here;
  • Blood glutathione-peroxidase levels in skin diseases “Depressed [glutathione] levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis”
  • read Biyanka’s testimonial here
  • watch Mandy’s video here
• ear health
  • listen to a call by Dr. Luiz Valdez about the importance of glutathione for ear health here
• emphysema
  • 91 scientific papers here
  • The Use of Nebulized Glutathione in the Treatment of Emphysema: a Case Report . We present the case of a 95-year-old man with an acute respiratory crisis secondary to emphysema and apparent bronchial infection. Treatment with nebulized glutathione led to a rapid resolution of the crisis, as well as a marked improvement in the chronic course of the disease. This treatment has been used since for a number of patients with emphysema. The safety and bioavailability of this method of delivery have been established in human studies. Preliminary results suggest efficacy for nebulized administration of glutathione in this patient population. We suggest this treatment can be considered an option for acute respiratory crises due to COPD.
  • Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994
• erectile dysfunction
  • 19 scientific papers here
• eyes
  • poor eyesight (8 scientific papers here)
  • Natural therapies for ocular disorders, part two: cataracts and glaucoma. “Pathophysiological mechanisms of cataract formation include deficient glutathione levels contributing to a faulty antioxidant defense system within the lens of the eye.”
  • An Impediment to Glutathione Diffusion in Older Normal Human Lenses “A common feature of nuclear cataract is the low concentration of reduced glutathione (GSH) in the center of the lens. GSH is the principal lenticular antioxidant of the lens and it is synthesized and regenerated in the lens cortex.”
  • read the American Healthcare Foundation’s article about glutathione and glaucoma here.
  • “The Russians A.I. Bunin, A.A. Filina and V.P. Erichev measured GSH levels in the eyes of hundreds of patients undergoing surgery for all sorts of reasons. The lowest GSH levels were found among cataracts patients and in patients with open angle glaucoma. They noticed this fall even at the earliest stages of the disease and suggested that reestablished glutathione levels would help prevent or delay this process.”
  • read a general article about the importance of glutathione and eye health here
• feet problems
  • read Paul’s testimonial here
  • read Evie’s testimonial here
• fetal alcohol syndrome
  • Gauthier TW, Ping XD, Harris FL, Wong M, Elbahesh H, Brown LA, Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatr Res. 2005 Jan;57(1):76-81.
• fibromyalgia
  • listen to how raising glutathione may benefit someone with fibromyalgia here
  • read the American Healthcare Foundation’s article about glutathione and fibromyalgia here. “The GSH molecule is found in each cell. Maintaining GSH levels help: support your Immune System modulation; slow progression of inflammation and disease; and minimize the side effects of pain medication.”
  • read Holly’s, Sally’s, Shirley’s and Gertie’s testimonials here
  • read Aline’s, Elenita’s, Maria’s, Julie’s and Ron’s testimonials here
  • read Bonnie’s testimonial here
  • read Karen’s testimonial (skip to the bottom of the page) here
• Gaucher’s disease
  • individuals with Gaucher’s disease have a deficiency in glutathione reductase (scientific study in German here). Glutathione reductase is an enzyme that reduces glutathione disulfide to the glutathione.
  • a clinical trial is planned for intravenous N-acetyl cysteine for the treatment of Gaucher’s disease (MaxGXL contains N-acetyl cysteine) here. They will be quantifying how glutathione levels change in response to the treatment.
• gastritis
  • Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Gut 42: 485-492, 1998
• gastroenteritis
  • 359 scientific papers here;
• gingivitis
  • 12 scientific papers here
• glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • an article about G6PD deficiency and glutathione here. “Glucose-6-phosphate dehydrogenase is an enzyme that uses metabolic reactions to provide the reducing capacity to keep glutathione in its reduced form (GSH) and available for its
    metabolic roles that include regeneration of vitamins C and E after they are oxidized while performing their antioxidant functions.”  As a result, glutathione levels are low in individuals with GDPD deficiency.
• gout
  • read the American Healthcare Foundation’s article about glutathione and gout here. ” Elevated GSH levels may help by: providing Immune System modulation, including less infection; and notably slowing any further arthritic progression. Raising glutathione levels enables a patient with gout to be less prone to painful and debilitating flare-ups.”
  • watch Robin’s video here
• gum disease
  • 67 scientific papers here
• headaches
  • 38 scientific papers here
  • watch Rosie’s video here
• heart disease
  • 408 scientific papers here
  • read these scientific papers about cardiovascular disease and glutathione here
  • Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes. Nutrition Reviews 54: 1-30, 1996.
  •  ”Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study.” Stroke. 2004 Sep; 35(9):2072-7.
  • “Glutathione Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic Subject.” Drugs Exp. Clin Res 1992
    18:493-98
  • Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease.  Increasing glutathione levels might lower the risk of cardiovascular events.
  • read the American Healthcare Foundation’s article about glutathione and heart disease here. “GSH protects your heart and brain in the event of an attack. GSH diminishes damage to oxygen-deprived tissue during and after the attack. GSH protects against lipid peroxidation – the process that turns cholesterol (a waxy fatty substance) rancid. This process causes cholesterol deposits to stick to the artery walls. GSH has been shown to prevent and even reverse hardening of the endothelial – the delicate elastic inner lining – a condition known as arteriosclerosis. There is overwhelming evidence that GSH combats free radical damage to your cardiovascular system – damage that occurs over time – setting the stage for a heart attack or stroke.”
  • read a general article about the importance of glutathione and the health of you heart here and  here
  • read David’s testimonial here
• heavy metal toxicity
  • 37 scientific papers here
  • Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. “There is evidence for antioxidant protection in the prevention of neurological and renal damage caused by mercury toxicity. Research has attempted to identify the role of antioxidants, glutathione and alpha-lipoic acid specifically, in both mitigation of heavy metal toxicity and direct chelation of heavy metals”
  • read these scientific papers about heavy metal toxicity and glutathione here
  • an article discussing the importance of glutathione for detoxing heavy metals of autistic children here and here. Glutathione is the body’s chief detoxifier.  It works with MT proteins to remove heavy metals and other harmful substances like pesticides and PCBs.
  • listen to how raising glutathione levels may benefit someone with heavy metal toxicity here
• Hepatitis A,B and C
  • 781 scientific papers here
  • The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raisied glutathione levels help restore liver function. American Journal of gastroenterology 91: 2569-2573, 1996
  • Clinical studies on MaxGXL included individuals with Hepatitis C. These individuals experienced a 270% increase in glutathione levels over a 3 month period (graph provided here)
• herpes
  • 165 scientific papers here
  • Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. Read here
• hormonal imbalance
  • read Laura’s testimonial here
• Huntington’s disease
  • 112 scientific papers here
  • Choo YS, Mao Z, Johnson GVW, and Lesort M. Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington’s disease mouse model. Neurosci Lett. 2005 Sep 23;386(1):63-8.
• hypertension or high blood pressure
  • 781 scientific papers here
  • read the American Healthcare Foundation’s article about glutathione and high blood pressure here.
  • “Fighting oxidative damage high GSH levels may help prevent the following complications of high blood pressure: Arteriosclerosis; heart attack; stroke; increased incidence of kidney failure; and side effects of medications”
  • Read this article about the link between excess free radicals and high blood pressure here. The research suggests that anti-oxidants may help prevent or treat high blood pressure. Glutathione is the body’s master anti-oxidant.
  • watch Tia’s video here.
• hyperthyroidism (162 scientific papers here)
  • read a Connor’s testimony, an individual with Grave’s disease (a form of hyperthyroidism) here. Watch his video here.
  • watch Conon’s video here
• hypoxia (stroke, tissue ischemia, inflammation, solid-tumor formation)
  • Mitochondrial glutathione (scientific review paper) – see p. 2690 for info re: hypoxia
• immune system
  • Droge W, Breitkreutz R, Glutathione and Immune Function. Proc Nutr Soc. 2000 Nov;59(4):595-600. “Immunological functions in diseases that are associated with a cysteine and glutathione deficiency may be significantly enhanced and potentially restored by cysteine supplementation”
• influenza
  • 94 scientific papers here
  • Cai J; Chen Y; Seth S; Furukawa S; Compans RW; Jones DP, Inhibition of influenza infection by glutathione. Free Radic Biol Med. 2003 Apr 1; 34(7):928-36.
• insomnia
  • 14 scientific papers here
  • read Laura’s testimonial here
  • read Sona’s point #14 (i.e., her husband started sleeping for the first time in 15 years) here.
  • read Patricia’s testimonial here
• joint pain
  • read Kerry’s and Donny’s testimonials here
  • watch Tia’s video here.
• kidney disease
  • Those with kidney failure or on dialysis suffer from high levels of oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia. Nephron 61: 404-408, 1992
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • Restoring glutathione as a therapeutic strategy in chronic kidney disease here
  • read a general article about glutathione and kidney health here
• liver
  • Mitochondrial glutathione (scientific review paper) – see p. 2692 for info re: liver
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • Dicky was dying of a liver disease and within 4 months of starting MaxOne, his liver was completely detoxed. Read his testimonial here.
  • read Jeff’s testimonial (his liver function improved)  here
  • read Ken’s testimonial here
• Lou Gehrig’s disease (see ALS above)
• lung disorders and COPD (chronic obstructive pulmonary disease)
  • read a general article about glutathione and lung health here
  • Mitochondrial glutathione (scientific review paper) – see p. 2694 for info re: lungs
  • The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione. The potential applications of inhaled GSH are numerous when one considers just how many pulmonary diseases and respiratory-related conditions are affected by deficient antioxidant status or an over production of oxidants, poor oxygenation and/or impaired host defenses.
  • Oxidative stress and regulation of glutathione in lung inflammation. This review describes the redox control and involvement of nuclear factor-kB and activator protein-1 in the regulation of cellular glutathione and c-glutamylcysteine synthetase under conditions of oxidative stress and inflammation, the role of glutathione in oxidant-mediated susceptibility/tolerance, c-glutamylcysteine synthetase genetic susceptibility and the potential therapeutic role of glutathione and its precursors in protecting against lung oxidant stress, inflammation and injury.
  • Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. This review outlines 1) the regulation of cellular GSH levels and g-GCS expression under oxidative stress and 2) the evidence for lung oxidant stress and the potential role of GSH in the pathogenesis of COPD.
  • The Use of Nebulized Glutathione in the Treatment of Emphysema: a Case Report . We present the case of a 95-year-old man with an acute respiratory crisis secondary to emphysema and apparent bronchial infection. Treatment with nebulized glutathione led to a rapid resolution of the crisis, as well as a marked improvement in the chronic course of the disease. We suggest this treatment can be considered an option for acute respiratory crises due to COPD.
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994
  • read scientific papers about COPD and obstructive pulmonary disease and glutathione here.
  • read a general article about glutathione and lung health here
  • watch Dr. Keller’s video where he talks about the benefits for COPD and glutathione here.
• lupus
  • 101 scientific papers here
  • Elevated levels of inflammatory markers were associated with a depletion of Glutathione in study subjects suffering from Lupus and Arthritis; scientific paper here.
  • read Joe’s testimonial  here
  • read Kerry’s and Julie’s testimonials here
• lyme disease
  • “Lyme disease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a soluble compound with them, which can then be excreted through the urine or gut.” Can Glutathione Help Lyme Disease Sufferers? Excerpt from: The Glutathione Report: Optimal Health with the Master Antioxidant. Issue 4, Volume 1, 2004 May.
  • Pancewicz, SA; Skrzydlewska E, et al, Role of reactive oxygen species (RPS) in patients with erythema migrans, and early manifestation of Lyme borreliosis. Med Sci Monit. 2001; 7(6): 1230-35. (A paper that essentially says that glutathione levels are low in individuals with lyme disease)
  • Dr. Klinghardt’s biological treatment of lyme disease based on 900 successful treated cases is here. (I highly respect Dr. Klinghardt. His protocol is very comprehensive, and one of the steps involves increasing glutathione levels).
  • read this article and testimonial about lyme disease and glutathione here
  • read Nancy and Christein’s testimonials here 
  • read Karen’s testimonial (skip to the bottom of the page) here
• macular degeneration
  • 78 scientific papers here
  • read these scientific papers about macular degeneration and glutathione here
• male infertility
  • 139 scientific papers here
• migraines
  • 10 scientific papers here
  • read Alan’s testimonial about migraines here. After 2.5 months, he no longer experiences pain associated with migraines. Watch his video here
  • read Laura’s testimonial here and her video here.
  • watch Ngarta’s video here
  • watch Tammy’s video here.
• mitochondrial health
  • Glutathione deficiency in patients with mitochondrial disease: implications for pathogenesis and treatment here. Restoration of cellular glutathione  could prove to be of therapeutic benefit in patients with a glutathione deficiency.
  • “Levels of glutathione were significantly reduced in white blood cells from the 20 mitochondrial disease patients in the study.” Read a news release from Stanford Medical school here and another article here.
• multiple sclerosis (MS)
  • 120 scientific papers here
  • Calabrese et al. Disruption of 6 Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine. 2003 Sep; 28(9):
    1321-8.
  • Mann et al. Glutathione S-Transferase Polymorphisms in MS: Their Relationship to Disability. Neurology. 2000 Feb 8;54(3):542-7.
  • Researchers concluded that in patients with secondary progressive multiple sclerosis that showed an absence of measurable inflammation, oxidative stress continued to cause a functional decline in the patients. This was shown by lower levels of glutathione in the brain (Choi Multiple Sclerosis 2011)
  • read these scientific papers about MS and glutathione here
  • read Mickey’s testimony here
• MRSA (9 scientific papers here)
• myocardia ischemia
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
• neurodegenerative disease
  • Mitochondrial glutathione (scientific review paper) – see p. 2693 for info re: neurological disorders.
  • Glutathione, oxidative stress and neurodegeneration. There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Friedreich’s ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders.
  • GSH and analogs in antiviral therapy. “GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx). An imbalance in GSH is observed in a wide range of pathologies, such as cancer, neurodegenerative diseases, cystic fibrosis (CF), several viral infections including HIV-1, as well as in aging.”
  • read these papers about neurodegenerative disease and glutathione here
  • One neurologist, Dr. Rex Anderson, has all of his patients on MaxGXL (watch his video here)
• obesity (402 scientific papers here)
• osteoarthritis
  • Hammarqvist F, Luo JL, cotgreave IA, Andersson K, Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill Patients. Crit Care Med. 25(1):78-84 1997 Jan.
  • Read Sally’s testimonial here
• osteoporosis (75 scientific papers here)
• ovarian tumour
  • read how Sona’s ovarian tumour disappeared  here.
• overtrained athletes
  • read this abstract here
• pain
  • 254 scientific papers here
  • read a testimonial about Linda who was experiencing chronic pain and fatigue here.
  • Read Jackie’s and Ken’s testimonial here
  • read Allion’s, Sherel’s, Mike’s,  Brian’s,  Maria’s, Christeen’s, Jeanne’s and Cheryl’s mom’s testimonials here
  • Read Christina’s testimonial here (in four days, her back pain was gone)
  • Read Dena’s story here
  • Watch Lyn’s video here
  • Watch Ngarta’s video here
  • Watch Diana’s video here
  • Watch Doug’s video here
  • Watch Ron’s video here
  • Watch Jerry’s video here
• pancreatitis
  • Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Gut 42: 485-492, 1998
• Parkinson’s disease
  • 798 scientific papers here;
  • read these scientific papers about Parkinson’s and glutathione here
  • New Advances in Parkinson’s Disease
  • Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration. Parkinson’s disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (SN). One of the earliest detectable biochemical alterations that occurs in the Parkinsonian brain is a marked reduction in SN levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex I (CI) activity, striatal dopamine levels, or midbrain dopaminergic neurodegeneration associated with the disease.
  • Glutathione, oxidative stress and neurodegeneration. There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Friedreich’s ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders.
  • Dopamine turnover and glutathione oxidation: Implications for Parkinson disease. Parkinson disease is characterized by a major loss (z8O% or more) of dopaminergic nigrostriatal neurons and by an increased turnover of neurotransmitter by surviving neurons of the nigrostriatal tract. In theory, increased turnover of dopamine should be associated with an oxidative stress derived from increased production of hydrogen peroxide.
  • Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: implications for Parkinson’s disease. Oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (SN) associated with Parkinson’s disease (PD). The SN of early PD patients have dramatically decreased levels of the thiol tripeptide glutathione (GSH). GSH plays multiple roles in the nervous system both as an antioxidant and a redox modulator.
  • Glutathione Depletion Switches Nitric Oxide Neurotrophic Effects to Cell Death in Midbrain Cultures Implications for Parkinson’s Disease . This study shows that alterations in GSH levels change the neurotrophic effects of NO in midbrain cultures into neurotoxic. Under these conditions, NO triggers a programmed cell death with markers of both apoptosis and necrosis characterized by an early step of free radicals production followed by a late requirement for signalling on the sGC/cGMP/PKG pathway.
  • Parkinson’s Disease as Multifactorial Oxidative Neurodegeneration: Implications for Integrative Management. Parkinson’s disease (PD) is the most common movement pathology, severely afflicting dopaminergic neurons within the substantia nigra (SN) along with non-dopaminergic, extra-nigral projection bundles that control circuits for sensory, associative, premotor, and motor pathways.
  • Reduced intravenous glutathionein the treatment of early Parkinson’s disease. Our data indicate that in untreated PD patients glutathione has symptomatic efficacy and possibly retards the progression of the disease.
  • Glutathione helps to preserve brain tissue by preventing damage from free radicals (acids) and destructive chemicals formed by the normal processes of metabolism, toxic elements in the environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection many be lacking in the brains of Parkinson’s clients due to glutathione deficiency, it can be seen as very beneficial. (Di Monte et al. Glutathione in Parkinson’s Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111- 115, 1992.)
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
  • Glutathione and Parkinson’s disease: Is this the elephant in the room? “At least 2 decades have past since the demonstration of a 40% deficit in total glutathione (GSH) levels in the substantia nigra [a part of the brain] in patients with Parkinson’s disease (PD).”
  • read a general article about the link between Parkinson’s and autism [i.e., low glutathione levels] here
  • a clinical trial is planned for intravenous N-acetyl cysteine for the treatment of Parkinsons’ disease (MaxGXL contains N-acetyl cysteine) here. They will be quantifying how glutathione levels change in response to the treatment.
  • see Dr. David Perlmutter’s video about the success of glutathione therapy for Parkinson’s here. Read an interview with him here.
  • read Jane’s testimonial here (she no longer needs a cane to walk and her energy levels have increased from a 2 to a 6 in three months)
• plantar fasciitis
  • read Ken’s testimonial here
  • read another testimonial about planter fasciitis here
• pre-eclampsia (hypertension during pregnancy)
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
• pregnancy
  • Glutathione’s role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels. Early Human Development 37: 167-174, 1994
• premenstrual syndrome (2 scientific papers here)
• psoriasis
  • 60 scientific papers here
  • Blood glutathione-peroxidase levels in skin diseases “Depressed [glutathione] levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis
  • Watch Mandy’s video here
• pulmonary fibrosis
  • 213 scientific papers here
  • Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994
  • Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis. These data confirm the established role of oxidant/antioxidant imbalance in the pathogenesis of idiopathic pulmonary fibrosis, and show the potential of induced sputum to directly study inflammatory processes and surrogate markers in interstitial lung diseases like idiopathic pulmonary fibrosis.
• restless leg syndrome
  • read Pat’s testimonial here
• schizophrenia
  • 165 scientific papers here
  • A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. When glutathione (GSH) levels are reduced there is an increased potential for cellular oxidative stress, characterised by an increase and accruement of reactive oxygen species (ROS). Oxidative stress has been implicated in the pathology of schizophrenia and bipolar disorder. Read this abstract here.
• seizures
  • read a testimony about Sue’s autistic son that no longer has seizures after starting MaxGXL here
  • read Maria’s testimonial here
• sepsis
  • 408 scientific papers here;
  • read a scientific paper entitled, “Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction” here. This paper discusses how individuals with sepsis have low glutathione levels and supplementation with cysteine can be a useful treatment (MaxGXL contains N-Acetyl Cysteine)
  • Read Lomaestro and Malone’s (1995) paper, Glutathione in Health and Disease: Pharmacotherapeutic Issues
• sinusitis
  • Kassim SK; Elbeigermy M; Nasr GF; Khalil R; Nassar M., The role of interleukin-12, and tissue antioxidants in chronic sinusitis. Clin Biochem. 2002 Jul; 35(5):369-75.
  • Uslu C; Taysi S; Bakan N., Lipid peroxidation and antioxidant enzyme activities in experimental maxillary sinusitis. Ann Clin Lab Sci. 2003 Winter; 33(1):18-22.
  • Westerveld GJ; Dekker I; Voss HP; Bast A; Scheeren RA, Antioxidant levels in the nasal mucosa of patients with chronic sinusitis and healthy controls. Arch Otolaryngol Head Neck Surg. 1997 Feb; 123(2):201-4.
• skin conditions
  • watch this testimonial video here
• sleeping disorders
  • 46 scientific papers here;
  • read John V.’s and Elaine’s testimonials here
  • read a testimonial about one person’s obstructive sleep apnea here
• spontaneous abortions
  • 49 scientific papers here
• stomach ulcers
  • Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Gut 42: 485-492, 1998
• stress
  • watch Rosie’s video here
• stroke
  • Nutritional Regulation of Glutathione in Stroke. Neurtox Res. 1999 Dec; 1(2): 99-112.
  • Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes. Nutrition Reviews 54: 1-30, 1996.
  • read these scientific papers about stroke and glutathione here
• tendonitis
  • read Mike’s testimonial here
• thyroid gland health
  • listen to the benefits of increasing glutathione levels for someone with thyroid gland issues here
  • watch Connor’s video here
  • watch Conon’s videohere
  • watch Tammy’s video here.
• TMJ disorder
  • Watch Ngarta’s video here
• upper respiratory problems (27 scientific papers here)
• viral infections (1075 scientific papers here)
  • Fraternale A, Paoletti MF, Casabianca A, et al, Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.
  • GSH and analogs in antiviral therapy. “GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx). An imbalance in GSH is observed in a wide range of pathologies, such as cancer, neurodegenerative diseases, cystic fibrosis (CF), several viral infections including HIV-1, as well as in aging.”
  • Clinical studies on MaxGXL included individuals with a chronic viral illness. These individuals experienced a 262% increase in glutathione levels over a 3 month period (graph provided here)

MaxGXL has been clinically proven to increase glutathione levels by an average of 276%.

The information described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. MaxGXL does not cure or treat any disease or illness. It simply gives your cells the nutrients they need to produce more glutathione, which in turn helps every cell function better.

Why glutathione production is important for autistic children

I first heard of glutathione while reading the book, “Healing and Preventing Autism” by Jenny McCarthy and Jerry Kartzinel. Although my son doesn’t have autism, I have found that many treatments that are known to help autistic children also help my son (who has a diagnosed immune disorder).

An entire chapter in McCarthy and Kartzinel’s book describes the importance of glutathione, how it is the most important substance that our body produces to help our immune system fight infections. It’s the body’s most important antioxidant and the body’s most powerful detoxifier. Most autistic children are low in glutathione (I’ve read that autistic children have 50% less intracellular glutathione than other children), which is why they have so much trouble detoxifing vaccines, medications, environmental toxins, toxins in food and why they have so much trouble fighting infections and diseases. Read a Talk about Curing Autism article about detoxification, glutathione and autism here.

Dr. Kartzinel discusses how many autistic children come from “poor methylating families”, meaning families that tend to have a difficult time producing glutathione (i.e., the overall function of the methylation pathway is under genetic control). Poor methylating families have a family history of depression, bipolar disease, schizophrenia, suicide, constipation, attention deficit disorder, alcoholism and, of course, autism. See also this list of diseases and illnesses that are linked to low glutathione levels. Furthermore, the methylation pathway is sensitive to environmental toxins, such as mercury. So a person who is exposed to a toxin (like mercury or aluminum) who is already undermethylating (i.e.,  under producing glutathione) will have an even more difficult time detoxing when exposed to such toxins. It turns into a vicious cycle.

Typically, glutathione is taken intravenously, transdermally or through a nebulizer. Note that supplementing directly with oral glutathione is generally not effective because studies have found that glutathione does not survive the digestive process. Furthermore, supplementing with oral glutathione can result in a yeast outbreak and gut imbalance. Watch a news story about autistic children receiving glutathione IV treatments here. Injections are only minimally useful, since glutathione cannot enter into the cells themselves. It must be manufactured inside the cells (when the necessary components are available.) As Dr. Kartzinel explains, methyl B12 injections and supplementing with trimethylglycine (TMG) or dimethylglycine (DMG),  folic acid and N-acetyl-cysteine can increase glutathione levels. Read Dr. Kartizel’s blog post about the methylation process, glutathione and autism here.

When I first read about glutathione, I knew that both my son and I needed to increase our glutathione levels, but it sounded so complicated to do. When I found out about a supplement that can be used to increase glutathione levels, a voice within me told me that it was a significant supplement that could help many individuals (including autistic children).

MaxGXL is an easy and effective method to increase intracellular glutathione levels. This supplement contains N-acetyl-cysteine as well as other ingredients that have been proven to increase glutathione levels by an average of 292%. Some individuals have been giving it to their autistic children, with some amazing results (read the full testimonies here).

• One seven year old boy started making eye contact and told his mom that he loved her for the first time within 6 weeks of starting MaxGXL.
• Within 5 days of starting MaxGXL, another boy became interested in playing with a baseball bat and hit the ball with a bat for the first time (a focused and purposeful activity). Additional changes: he now goes to school in a mainstream classroom for almost the entire day; his stool is now normal; he is now in accelerated language development; and he no longer requires a special diet.
• After two months of being on MaxGXL, a 10 year old boy started making better eye contact, he stopped having temper tantrums, he started becoming more affectionate, he started listening and following instructions, and he started speaking in sentences.
• Read about another mother’s experience with MaxGXL. “After only a few months on the product, I can honestly tell you that I fully support this glutathione accelerator, because I’ve seen the actual results in what it’s done for me, my husband, my parents, my son and my friends.   [The changes] I saw in my son were immediate detox effects through his stool and increased hyperactivity. After a few days of that, his stool and behavior regulated and has stayed regulated except for when he’s been sick. He also started processing a lot better – I call it “firing on all cylinders”. I noticed him responding a lot faster to not only our direct conversations with him, but also indirectly commenting on things we were talking about in a different room or in the car. Also, his glutathione levels increased a lot… we did testing that proved the increased levels”.
• “Hi my name is Sue, I live in Melbourne and I have a 15-year old son, Sam, who is autistic. He has been taking Max since April last year. He started in high school, at the beginning of last year, which is a huge transition for him. He is a high functioning child had an integration age aid through primary school, no aid at secondary school and was really struggling in term 1. I started him on Max GXL and he is a totally different child. He doesn’t get exhausted like he used to, he would come home from school totally exhausted, he had no energy to do his homework, it was a nightmare. He can concentrate at school. Before he would only get half the information and he also has epilepsy and is now off his epilepsy medication and no seizures, no signs of seizures. I send Max to school with him in his lunch box. If he’s getting tired, if he’s getting stressed, he takes it. But now he’s really stable at the moment and functioning at a much higher level. He bought home the best school report last year and he’s happy, more confident and just doesn’t get tired.” Watch Youtube video here.

Dr. Corinne Allen discusses brain injuries, autism, and MaxGXL

“MaxGXL® has been the most significant product that I have ever used for the nutritional support of the brain and nervous system. I have never seen such fast, amazing and life-changing results from a single nutritional supplement. I work with all levels of brain injuries, mild to severe, and I find that from babies on up, if they have brain, emotional or developmental issues, they are severely lacking in glutathione.”

• Click here to listen to Dr. Corinne Allen discussing brain injuries, autism and MaxGXL.
• Click here  to listen to Dr. Corinne Allen discussing neurodevelopment, autism, and the effectiveness of MaxGXL.
• Click here for notes from Dr. Corinne Allen’s call.
• Click here for article about autism and glutathione published in the American Journal of Clinical Chiropractic.

Is MaxGXL safe for children?

I should mention that the MaxGXL box states that MaxGXL is not to be used for children. As Dr. Corinne Allen says, “The reason the (MaxGXL) box … says not to use in children and pregnancy is because Dr Keller (hadn’t) personally done all the studies with THIS glutathione. His focus was adults.“

As with all things, I feel that parents should do as much reading as they can about MaxGXL and also see what their intuition says about whether they want to try this with their children.

Several parents are giving their children MaxGXL with amazing results. In addition to the stories above, read about another parent’s experience with giving MaxGXL to her 10 year old daughter MaxGXL here. After two months of being on MaxGXL, Her daughter is now able to wake up easily, doesn’t tire as easily, can focus on school work easily and doesn’t want to drink soda anymore. Read Donna’s story on page 3 of this list of testimonies about how Donna’s five year old son’s intense tantrums (lasting for 2-3 hours) diminished within one month and he is now much calmer, kind and gentler, and open to trying new foods.

A good guideline is 1 capsule of MaxGXL for every 25 lbs. of weight per day. I would start with just a sprinkle, and then gradually work your way up from there. For example, if your child is 50 lbs, you would gradually work your way up to 1 capsule in the morning and 1 in the afternoon.

If your child cannot swallow a capsule, you can open up the capsule and mix contents in apple sauce, yogurt, juice, shake, oatmeal, cereal, on toast, etc.

Allergy warning: MaxGXL is derived from mushrooms and shellfish, therefore, if your child is allergic to either of these foods, then you can use MaxOne instead, which is another Max product that is not derived from mushrooms or shellfish. MaxOne is 300% more potent than MaxGXL, therefore, your child will need a lot less (i.e., 1/3 of a capsule for every 25 lbs).

Connect with other parents

I have started a Yahoo Group for parents who are giving their children MaxGXL or MaxOne, or who are considering doing so here.

Additional reading

• read these scientific papers about autism and glutathione here
• a general article about the link between Parkinson’s disease and autism [i.e., low glutathione levels] here;
• Scientific paper: “A clinical trial of glutathione supplementation in autism spectrum disorders” here (note that they did not test MaxGXL specifically, but this study shows that scientists feel that there is scientific merit to increasing glutathione levels in autistic children).
• Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15. “We conclude that that 45% of a subgroup of children with autism suffers from low NK cell activity, and that low intracellular levels of glutathione, IL-2 and IL-15 may be responsible.”
• Mercury and autism: Accelerating Evidence? “The process of cysteine and glutathione synthesis, which are crucial for natural mercury detoxification, are reduced in autistic children, possibly due to genetic polymorphisms [13,30]. Therefore, autistics have 20% lower plasma levels of cysteine and 54% lower levels of glutathione, which, among others, adversely affect their ability to detoxify and excrete metals like mercury”
• Biomarkers of environmental toxicity and susceptibility in autism. “Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, and sulfate were observed among study participants relative to controls. The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity.”
• read an article by American Healthcare Foundation about glutathione and autism here. “A study performed at the University of Arkansas for Medical Sciences College of Medicine suggested that excessive cellular oxidative stress may be a factor causing autism. In the study, researchers measured plasma glutathione and its metabolic precursors in 95 autistic children and 75 children without autism. It was found that levels of glutathione are significantly lower in autistic children than in the children without autism.”
• an article discussing the importance of glutathione for detoxing heavy metals of autistic children here and here. Glutathione is the body’s chief detoxifier.  It works with MT proteins to remove heavy metals and other harmful substances like pesticides and PCBs. Dr. S. Jill James has shown that 90% of children on the  autism spectrum as well as their parents have impaired methylation.  The active form of glutathione is reduced 80% in kids with autism.

The information described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. MaxGXL does not cure or treat any disease or illness. It simply gives your cells the nutrients they need to produce more glutathione, which in turn helps every cell function better.

Testimonials of individuals taking MaxGXL

Virtually everyone who takes Max products consistently for three months feels a difference (i.e., higher energy levels and other health benefits). 75% of people feel a difference within a week, and 90% within two weeks feel a difference. I felt a difference in my mental clarity within hours of first taking MaxGXL. Studies have shown that 100% of the people taking MaxGXL increased their intracellular glutathione levels by an average of 276% to 292% after 60 days.

“Ever since I have started taking MaxGXL, my life has changed dramatically. I am no longer constantly fatigued, or have fainting spells. My migraine headaches have decreased by 90%. My hair which was dry, brittle and dead, is now lustrous and alive. My skin is so soft, my nails no longer split. My energy levels have dramatically increased. I am getting the best sleep that I ever had in my life. MaxGXL also helps me to cope with stress in my life. It eases my anxiety and improves my mood.” Charlotte, St. John’s, Newfoundland

“Over the years I have tried many natural products. Nothing has ever worked so well (and continues to do so!) as MaxGXL. After only three days on MaxGXL, I could not believe how much better my left hand was. Another pleasant surprise is my balance, which has been terrible since a back operation in 1972. My balance now has greatly improved. The best improvement, I believe, is my energy level. I sleep so much better and wake up ready to GO! I am 70 years young and have the same or more zip than when I was 39! Thank you, MaxGXL!” George Richer, Ottawa, Ontario

Athletes

MaxGXL Sport carries the prestigious NSF Certified for Sport™ certification to ensure the product is free from substances on the banned substances list. Ideal for everyone from professional athletes to the average person, it contains the same ingredients as regular MaxGXL, only packaged using veggie caps and sealed in a convenient bottle.

**World class athletes have broken 14 world records using MaxGXL and MaxOne!**

• With the help of MaxGXL, Bill Gillespie broke four world records for power lifting in a single day at 49 years of age. Watch video here.
• With the help of MaxGXL, Evander Holyfield came out of retirement and became the 5 times world heavy weight champion in boxing at the age of 47 years of age. Watch video here.

• I started on the product in January 2008, almost one year after serious health problems. Within 2 weeks of starting MaxGXL, I noticed my energy level had risen. I had more energy to get myself to the gym, I started lifting heavier weights, started to run on the treadmill, which I had not done for a few years. I started to do the things that I really wanted to do. I’m now exercising five times a week since I have more energy to do it. I am eating better, and not craving all the junk I used to eat because I don’t feel stress like I did before. I am not waking up during the night. I am able to sleep better and therefore feel refreshed every morning now when I wake up. I have dropped weight since I have the energy to burn more calories. I really feel like a new man! Fernando Torres, Corana, CA
  

• Like so many people who first hear of MaxGXL, I had my doubts about what it could do for me and how it would improve my life. I was approached by a good friend of mine named Gary. He told me he wanted to show me this new product that would improve my overall health and improve my physical performance. I was intrigued because I was thinking about competing in the World Police and Fire Games for Karate in British Columbia in 2009. I am a firefighter for the city of Mississauga, Ontario and for the past while I wanted to get back into competing. I hold a black belt in Tae Kwon Do. I used to compete all the time but for the past ten years my focus went to other things. I never stopped running, stretching and lifting weights but as far as martial arts and competition, I was out of fighting shape. I knew that if I was going to do this, I needed all the help I could get. Gary explained the inner workings of Glutathione and MaxGXL. To say the least, I was interested. My third day on MaxGXL I had one of my best Karate classes to date. My cardio was limitless that night. The hour long class was actually not long enough! I could have gone for a second hour. It was then that I knew I had to keep taking this stuff. On April 12th, 2008 I came out of retirement having competed in my first local Karate tournament. I placed first in my division and second for Grand Champion. I owe a large part of this to MaxGXL.  Steve Holleran, Mississauga, Ontario
  
• Watch some videos by top athletes to see what they have to say about Max products here.
• More information about sports certification and Max products here.

Health Testimonials

Read some health testimonials here, which are summarized below.

• Linda’s chronic pain disappeared within 8 weeks of starting MaxGXL.
• Dicky was dying of a liver disease and within 4 months of starting MaxOne, his liver was completely detoxed.
• Kaye had a brain surgery to remove a mass and was suffering from seizures and short and long-term memory loss. Within 5 days of starting Max products, she was remembering things that she had forgotten for over 9 years. She is now completely symptom-free.
• Bill was in constant pain for 25 years. Within 10 days of starting MaxGXL, his pain disappeared and has never returned. As a result, he has been able to establish healthier relationships with his family members.
• Donna’s five year old son was having terrible tantrums that lasted for 2-3 hours at a time. Within a month’s time, the tantrums subsided. He is now gentle and kind and tantrum-free.
• Lesley suffered from pain in her legs. She has been taking MaxOne for 9 months and is feeling better, sleeping better, has amazing energy.
• Jim had problems with his parathyroid and thyroid glands and other endocrine glands, likely as a result of toxic exposures as a lab technician. Within 3-4 days of starting Max, he noticed a significant reduction in joint pain, neck pain and migraines. His energy levels have increased, sleep has improved, joint pain is gone and neck issues are gone.
• Anonymous – had terrible migraines throughout her life. Within three months of starting MaxOne, her migraines were completely gone.
• Watch Melissa’s video about her first 8 days on MaxGXL (better sleep, reduced food cravings, more energy) here

Read more health testimonials here.  

• anxiety
  • Ever since I have started taking MaxGXL, my life has changed dramatically. MaxGXL  helps me to cope with stress in my life. It eases my anxiety and improves my mood. Charlotte, St. John’s, Newfoundland
  • Rosie’s video here
  • read Peter’s testimonial here
  • read Christeen’s and Ron’s testimonials here
• arthritis
  • read Shirley’s testimonial here
  • read Kimberly’s, Kerry’s stepfather’s,  Mike’s, Gwendolyn’s and Michelle’s testimonials here
• asthma
  • Watch Ty Sutherland’s testimonial on Youtube here. Two months after starting MaxGXL, he no longer needs any asthma medications and his energy levels are through the roof.
  • Read Lisa’s testimonial about how her son no longer suffers from asthma here.
• attention deficit hyperactivity disorder (ADHD)
  • Watch Robin’s testimonial about her grandson with ADHD and depression here.
• autism
  • Read some amazing testimonials by parents of autistic children here.
  • One seven year old boy started making eye contact and told his mom that he loved her for the first time within 6 weeks of starting MaxGXL.
  • Within 5 days of starting MaxGXL, another boy became interested in playing with a baseball bat and hit the ball with a bat for the first time (a focused and purposeful activity). Additional changes: he now goes to school in a mainstream classroom for almost the entire day; his stool is now normal; he is now in accelerated language development; and he no longer requires a special diet.
  • After two months of being on MaxGXL, a 10 year old started making better eye contact, he stopped having temper tantrums, he started becoming more affectionate, he started listening and following instructions, and he started speaking in sentences.
  • Read about another mother’s experience with MaxGXL. “After only a few months on the product, I can honestly tell you that I fully support this glutathione accelerator, because I’ve seen the actual results in what it’s done for me, my husband, my parents, my son and my friends.   I saw in my son were immediate detox effects through his stool and increased hyperactivity. After a few days of that, his stool and behavior regulated and has stayed regulated except for when he’s been sick. He also started processing a lot better – I call it “firing on all cylinders”. I noticed him responding a lot faster to not only our direct conversations with him, but also indirectly commenting on things we were talking about in a different room or in the car. Also, his glutathione levels increased a lot (don’t have the exact % with me right now), but we did testing that proved the increased levels”.
  • “Hi my name is Sue, I live in Melbourne and I have a 15-year old son, Sam, who is autistic. He has been taking Max since April last year. He started in high school, at the beginning of last year, which is a huge transition for him. He is a high functioning child had an integration age aid through primary school, no aid at secondary school and was really struggling in term 1. I started him on Max GXL and he is a totally different child. He doesn’t get exhausted like he used to, he would come home from school totally exhausted, he had no energy to do his homework, it was a nightmare. He can concentrate at school. Before he would only get half the information and he also has epilepsy and is now off his epilepsy medication and no seizures, no signs of seizures. I send Max to school with him in his lunch box. If he’s getting tired, if he’s getting stressed, he takes it. But now he’s really stable at the moment and functioning at a much higher level. He bought home the best school report last year and he’s happy, more confident and just doesn’t get tired.” Watch Youtube video here.
• auto immune disorder
  • read Joe’s testimonial about his wife with lupus here
• back injury
  • read James’ testimonial here
  • read Dena’s story here
• back pain
  • read Cristina’s testimonial here (her back pain was gone in 4-5 days)
  • read Tolbert’s testimonial here (his back pain from a herniated disc is gone)
• bronchitis
  • read Pam and Julie’s testimonials here (in the comments section) (they both no longer get bronchitis regularly like they used to).
• burn
  • read how Sona’s burn healed quicklyhere.

cancer

• breast cancer
  • read Claudia’s testimony about detoxing the silicon resulting from silicon implant burst here
• cervical cancer
  • watch Tammy’s video here.
• lymphoma
  • read Lee’s testimony about his recovery from the chemo related to lymphoma here
• pancreatic cancer
  • read Sherel’s dad’s story here
• prostrate cancer
  • read Tolbert’s story here (cancer is now in remission)
• skin cancer
  • read Marie’s testimonial about how her precancerous skin cells were resolved here
• stomach cancer
  • read Carmen’s testimonial about how her daughter’s stomach  polyps no longer were cancerous here.

• candida
  • watch Maddie’s testimonial here
• chemical sensitivities
  • read Shirley’s testimonial here
• cholesterol
  • read Ken’s testimonial here
  • read Claudia’s testimonial here
• chronic fatigue syndrome / myalgic encephalomyelitis (ME)
  • Ever since I have started taking MaxGXL, my life has changed dramatically. I am no longer constantly fatigued, or have fainting spells. My migraine headaches have decreased by 90%. My hair which was dry, brittle and dead, is now lustrous and alive. My skin is so soft, my nails no longer split. My energy levels have dramatically increased. I am getting the best sleep that I ever had in my life. MaxGXL also helps me to cope with stress in my life. It eases my anxiety and improves my mood. Charlotte, St. John’s, Newfoundland
  • read Holly’s and Shirley’s testimonials here.
  • read Brian’s testimonial here
• cravings
  • read how Sona no longer craves Coke, and how her friend no longer craves coffee here.
• Crohn’s disease
  • watch Paul’s testimonial here.
• degenerative disc disease
  • Read Sally’s,  Julie’s and Shirley’s testimonies here
• depression
  • read Shirley’s testimonial here
  • read Ron’s testimonial here
  • Watch Diana’s video here
  • read Dena’s story here
• diabetes
  • Read Sally’s and Dave’s testimonials here
  • Read Larry’s and Christeen’s testimonials here
• eczema
  • read Biyanka’s testimonial here
  • watch Mandy’s video here
• feet problems
  • read Paul’s testimonial here
  • read Evie’s testimonial here
• fibromyalgia
  • read Holly’s, Sally’s, Shirley’s and Gertie’s testimonials here
  • read Aline’s, Elenita’s, Maria’s, Julie’s and Ron’s testimonials here
  • read Bonnie’s testimonial here
  • read Karen’s testimonial (skip to the bottom of the page) here
• gout
  • watch Robin’s video here
• headaches
  • watch Rosie’s video here
• heart disease
  • read David’s testimonial here
• hormonal imbalance
  • read Laura’s testimonial here
• hypertension or high blood pressure
  • watch Tia’s video here.
• hyperthyroidism
  • watch Connor’s testimony, an individual with Grave’s disease (a form of hyperthyroidism) here.
  • watch Conon’s video here
• insomnia
  • Ever since I have started taking MaxGXL, my life has changed dramatically. I am getting the best sleep that I ever had in my life. MaxGXL also helps me to cope with stress in my life. It eases my anxiety and improves my mood. Charlotte, St. John’s, Newfoundland
  • read Laura’s testimonial here
  • read Sona’s point #14 (i.e., her husband started sleeping for the first time in 15 years) here.
  • read Patricia’s testimonial here
• joint pain
  • read Kerry’s and Donny’s testimonials here
  • watch Tia’s video here.
• liver
  • Dicky was dying of a liver disease and within 4 months of starting MaxOne, his liver was completely detoxed. Read his testimonial here.
  • read Jeff’s testimonial (his liver function improved)  here
  • read Ken’s testimonial here
• lupus
  • read Joe’s testimonial about his wife’s recovery from Lupus after starting MaxGXL here
  • read Kerry’s and Julie’s testimonials here
• lyme disease
  • read Nancy and Christein’s testimonials here 
  • read Karen’s testimonial here (skip to the bottom of the page)
• migraines
  • Ever since I have started taking MaxGXL, my life has changed dramatically changed. My migraine headaches have decreased by 90%. Charlotte, St. John’s, Newfoundland
  • Watch Alan’s testimonial  here
  • read Laura’s testimonial here and her video here.
  • watch Ngarta’s video here
  • watch Tammy’s video here.
• multiple sclerosis (MS)
  • read Mickey’s testimony here
• osteoarthritis
  • Read Sally’s testimonial here
• ovarian tumour
  • read how Sona’s ovarian tumour disappeared  here.
• pain
  • read a testimonial about Linda who was experiencing chronic pain and fatigue here.
  • Read Jackie’s and Ken’s testimonial here
  • read Allion’s, Sherel’s, Mike’s,  Brian’s,  Maria’s, Christeen’s, Jeanne’s and Cheryl’s mom’s testimonials here
  • Watch Lyn’s video here
  • Watch Ngarta’s video here
  • Watch Diana’s video here
  • Watch Doug’s video here
  • Watch Ron’s video here
  • Watch Jerry’s video here
• Parkinson’s disease
  • read Jane’s testimonial here (she no longer needs a cane to walk and her energy levels have increased from a 2 to a 6 in three months)
• plantar fasciitis
  • read Ken’s testimonial here
  • read another testimonial about planter fasciitis here
• psoriasis
  • Watch Mandy’s video here
• restless leg syndrome
  • read Pat’s testimonial here
• seizures
  • read a testimony about Sue’s autistic son that no longer has seizures after starting MaxGXL here
  • read Maria’s testimonial here
• skin conditions
  • watch this testimonial video here
• sleeping disorders
  • read John V.’s and Elaine’s testimonials here
  • read a testimonial about one person’s obstructive sleep apnea here
• stress
  • watch Rosie’s video here
• tendonitis
  • read Mike’s testimonial here
• thyroid gland health
  • watch Connor’s video here
  • watch Conon’s video here
  • watch Tammy’s video here.
• TMJ disorder
  • Watch Ngarta’s video here

Hear what doctors have to say about Max products here.

These stories are are meant to be a sources of information. The information described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. MaxGXL does not cure or treat any disease or illness. It simply gives your cells the nutrients they need to produce more glutathione, which in turn helps every cell function better.